Article
Human cord blood antibody repertoire. Mixed population of VH gene segments and CDR3 distribution in the expressed C alpha and C gamma repertoires.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1993
Mortari F, Wang J Y, Schroeder H W
Abstract excerpt
Developmental regulation of the diversity of the antibody repertoire is associated with the controlled stepwise acquisition of Ag responsiveness during ontogeny. The development of IgG and IgA serum levels in humans lags far behind the maturation of the rest of the immune response. We cloned cord...
Topics
- Amino Acid Sequence
- B-Lymphocytes
- Base Sequence
- Fetal Blood
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
- Genes, Immunoglobulin
- Humans
- Immunoglobulin A
- Immunoglobulin G
- Liver
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- RNA, Messenger
- Sequence Alignment