Article
A molecular investigation of the obese phenotype in the Aston University strain of ob/ob mice and the Japanese Kuo Kondo mice.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Feb 1998
Fraser D C, Srivastava J, Woodward C J, Simpson A E, Jones R B
Abstract excerpt
The aim of this work was to determine the role of the ob gene in the obese phenotype observed in the Aston University Strain of ob/ob mouse and the Japanese Kuo Kondo (KK) mouse. After RT-PCR amplification of the ob RNA, the transcript was cloned into the vector pCR3 and three individual clones from each strain were sequenced. It was confirmed that the Aston University strain of ob/ob mice shared the same C-T...
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