Article
A molecular investigation of the obese phenotype in the Aston University strain of ob/ob mice and the Japanese Kuo Kondo mice.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Feb 1998
Fraser D C, Srivastava J, Woodward C J, Simpson A E, Jones R B
Abstract excerpt
The aim of this work was to determine the role of the ob gene in the obese phenotype observed in the Aston University Strain of ob/ob mouse and the Japanese Kuo Kondo (KK) mouse. After RT-PCR amplification of the ob RNA, the transcript was cloned into the vector pCR3 and three individual clones f...
Topics
- Animals
- Base Sequence
- DNA Primers
- Disease Models, Animal
- Leptin
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Mice, Obese
- Obesity
- Phenotype
- Polymerase Chain Reaction
- Proteins