Article
The molecular basis of the obese mutation in ob2J mice.
Genomics - 15 May 1997
Moon B C, Friedman J M
Abstract excerpt
The recessive ob2J mutation in mice results in an obese phenotype that is identical to that of the original ob allele. Initial studies indicated that ob2J mice fail to synthesize ob RNA in adipose tissue. Here we report the genomic organization of the mouse obese gene and establish the molecular genetic basis of the ob2J mutation. The ob2J mutation is the result of the insertion of a retroviral-like tranposon in...
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