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Article

Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice.

Endocrinology - 1 Jul 2004

Haluzik Martin, Colombo Carlo, Gavrilova Oksana, Chua Streamson, Wolf Nicole, Chen Min, Stannard Bethel, Dietz Kelly R, Le Roith Derek, Reitman Marc L

Abstract excerpt

We studied the effects of genetic background on the phenotype of ob/ob mice, a model of severe obesity, insulin resistance, and diabetes caused by leptin deficiency. Despite a comparable degree of obesity and hyperinsulinemia, C57BL/6J ob/ob mice had much milder hyperglycemia and, surprisingly, n...

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Identifiers

PMID: 15059949
DOI: 10.1210/en.2004-0219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15059949-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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