Mutational spectrum in the neurofibromatosis type 2 gene in sporadic and familial schwannomas.

doi:10.1007/s004390050188

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Article

Mutational spectrum in the neurofibromatosis type 2 gene in sporadic and familial schwannomas.

Human genetics - 1 Aug 1996

Welling D B, Guida M, Goll F, Pearl D K, Glasscock M E, Pappas D G, Linthicum F H, Rogers D, Prior T W

Abstract excerpt

Using a heteroduplex approach and direct sequencing, we have completed the screening of approximately 88% of the neurofibromatosis type 2 (NF2)-coding sequence of DNA extracted from 33 schwannomas from NF2 patients and from 29 patients with sporadic schwannomas. The extensive screening has result...

Topics

Codon
CpG Islands
DNA Mutational Analysis
DNA, Neoplasm
Genes, Neurofibromatosis 2
Humans
Mutation
Neurilemmoma
Neurofibromatosis 2
Polymerase Chain Reaction

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