Helicobacter pylori cagA Promoter Region Sequences Influence CagA Expression and Interleukin 8 Secretion.

doi:10.1093/infdis/jiv467

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Article

Helicobacter pylori cagA Promoter Region Sequences Influence CagA Expression and Interleukin 8 Secretion.

The Journal of infectious diseases - 15 Feb 2016

Ferreira Rui M, Pinto-Ribeiro Ines, Wen Xiaogang, Marcos-Pinto Ricardo, Dinis-Ribeiro Mário, Carneiro Fátima, Figueiredo Ceu

Abstract excerpt

Heterogeneity at the Helicobacter pylori cagA gene promoter region has been linked to variation in CagA expression and gastric histopathology. Here, we characterized the cagA promoter and expression in 46 H. pylori strains from Portugal. Our results confirm the relationship between cagA promoter region variation and protein expression originally observed in strains from Colombia. We observed that individuals with...

Topics

Adult
Aged
Antigens, Bacterial
Bacterial Proteins
Case-Control Studies
Epithelial Cells
Female
Gene Expression
Genetic Variation
Helicobacter Infections
Helicobacter pylori

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Interleukin-8

Male

Middle Aged

Portugal

Promoter Regions, Genetic

Young Adult

Source

Open in PubMed

Identifiers

PMID: 26401027
DOI: 10.1093/infdis/jiv467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26401027-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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