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Article

Sensitivity of p53 lysine mutants to ubiquitin-directed degradation targeted by human papillomavirus E6.

Virology - 1 Mar 1996

Crook T, Ludwig R L, Marston N J, Willkomm D, Vousden K H

Abstract excerpt

The activity of the p53 tumor suppressor protein is regulated, at least in part, through the stability of the protein. p53 degradation in normal cells is controlled by ubiquitin-dependent proteolysis, and activation of p53 following DNA damage is associated with an increase in the stability of the protein. The human papillomavirus-encoded E6 protein abrogates p53 function by targeting it for rapid degradation,...

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Identifiers

PMID: 8599213
DOI: 10.1006/viro.1996.0115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Sensitivity of p53 lysine mutants to ubiquitin-directed degradation targeted by human papillomavirus E6.PMID 8599213Read ↗

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.Semantic proximity Read ↗

Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteinsSemantic proximity Read ↗

High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradationSemantic proximity Read ↗

Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cellsSemantic proximity Read ↗

Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6Semantic proximity Read ↗

Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase.Semantic proximity Read ↗

The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrestSemantic proximity Read ↗

Degradation of HPV20E6 by p53: Delta Np63 alpha and mutant p53R248W protect the wild type p53 mediated caspase-degradation.Semantic proximity Read ↗

Functional inactivation of p73, a homolog of p53 tumor suppressor protein, by human papillomavirus E6 proteins.Semantic proximity Read ↗

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation.Semantic proximity Read ↗

Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function.Semantic proximity Read ↗

Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53.Semantic proximity Read ↗

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