Article
Sensitivity of p53 lysine mutants to ubiquitin-directed degradation targeted by human papillomavirus E6.
Virology - 1 Mar 1996
Crook T, Ludwig R L, Marston N J, Willkomm D, Vousden K H
Abstract excerpt
The activity of the p53 tumor suppressor protein is regulated, at least in part, through the stability of the protein. p53 degradation in normal cells is controlled by ubiquitin-dependent proteolysis, and activation of p53 following DNA damage is associated with an increase in the stability of th...
Topics
- Animals
- Base Sequence
- DNA
- Humans
- Lysine
- Mice
- Molecular Sequence Data
- Mutation
- Oncogene Proteins, Viral
- Papillomaviridae
- Protein Binding
- Transcription, Genetic
- Tumor Suppressor Protein p53
- Ubiquitins