Article

Non-classical glycosylation determines intracellular trafficking of APP and Aβ production

2022-06-22

Abstract excerpt

A primary pathology of Alzheimer’s disease (AD) is Aβ deposition in brain parenchyma and blood vessels, the latter being called cerebral amyloid angiopathy (CAA). Parenchymal amyloid plaques presumably originate from neuronal Aβ precursor protein (APP), but vascular amyloid deposits’ origins remain unclear. Endothelial APP expression in APP-knock-in mice was recently shown to expand CAA pathology, highlighting end...

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Literature Corpus work: 2aa61b35-8b62-5116-897d-f1730ab223e6
DOI: 10.1101/2022.06.20.496769

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