Article
Analysis of mutations in alleles of the fur gene from an endoprotease-deficient Chinese hamster ovary cell strain.
Somatic cell and molecular genetics - 1 Jan 1995
Spence M J, Sucic J F, Foley B T, Moehring T J
Abstract excerpt
RPE.40 mutant cells differ from wild-type Chinese hamster ovary (CHO-K1) cells in their increased resistance to Pseudomonas exotoxin A and their inability to process the insulin proreceptor and certain viral envelope proproteins. Northern analysis revealed that RPE.40 cells maintained a substantially lower steady-state level of 4.0 kb fur mRNA than did CHO-K1 cells. Analysis of fur cDNAs showed that RPE.40 cells...
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