Article
Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase.
Virology - 10 Jan 1995
Jacobson J, Kramer M, Rozenberg F, Hu A, Coen D M
Abstract excerpt
Herpes simplex virus encodes proteins, such as DNA polymerase, that are essential for its replication and proteins, such as thymidine kinase, that are not essential for replication in cell culture, but are important for pathogenesis in animal models. However, certain mutations affecting these pro...
Topics
- Animals
- Antiviral Agents
- Base Sequence
- Chlorocebus aethiops
- DNA, Viral
- Ganglia
- Genes, pol
- Herpes Simplex
- Molecular Sequence Data
- Mutation
- Nucleic Acid Synthesis Inhibitors
- Organic Chemicals
- Simplexvirus
- Thymidine Kinase
- Vero Cells
- Virus Replication