Article
Regulatory elements required for human angiotensinogen expression in HepG2 cells are dispensable in transgenic mice.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 1998
Yang G, Sigmund C D
Abstract excerpt
Previous researchers have identified two sequences present upstream (angiotensinogen gene-activating element [AGE2]) and downstream (d61-2) of the human angiotensinogen gene that act as cell-specific enhancers of transcription in transiently transfected HepG2 cells. To examine the importance of t...
Topics
- Angiotensinogen
- Animals
- Enhancer Elements, Genetic
- Gene Expression
- Gene Transfer Techniques
- Genes, Reporter
- Humans
- In Situ Hybridization
- Kidney
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutagenesis
- Mutation
- Regulatory Sequences, Nucleic Acid
- Tumor Cells, Cultured