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Article

Induction of the neoplastic phenotype of EBV-established B lymphocytes by the human Ha-ras oncogene.

Oncogene - 1 Jan 1990

Nasi S, Sirinian M I, Panetta G, Marchetti A, Jucker R

Abstract excerpt

We report on the use of human B lymphocytes immortalized by the Epstein-Barr virus (EBV) as targets for transformation by the c-Ha-ras oncogene of bladder carcinoma cells T24. Several stably transformed cell lines were obtained and their in vivo and in vitro growth properties as well as levels of expression of the ras gene were studied. The transformed phenotype in these cells was correlated to ras oncoprotein...

Topics

Animals
B-Lymphocytes
Cell Line, Transformed
Cell Transformation, Neoplastic
DNA
Genes, ras
Herpesvirus 4, Human
Humans
Mice
Phenotype
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 2157177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2157177-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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