Article
Mutated c-Ha-ras oncogene alters cytokeratin expression in the human breast epithelial cell line MCF-10A.
The American journal of pathology - 1 Jun 1992
Paine T M, Fontanini G, Basolo F, Geronimo I, Elliott J W, Russo J
Abstract excerpt
MCF-10A, a spontaneously immortalized human breast epithelial cell line, has been transformed by transfection with the mutated c-Ha-ras oncogene obtained from T24 carcinoma cells. The pattern of cytokeratin expression was studied in MCF-10A cells in comparison with plasmid transfected or MCF-10Aneo cells, normal ras proto oncogene transfected or MCF-10AneoN cells, and transformed or MCF-10AneoT cells. Cytokeratin...
Topics
- Blotting, Western
- Breast
- Cell Line, Transformed
- Genes, ras
- Humans
- Keratins
- Mutation
- Proto-Oncogene Mas