Activated c-Ha-ras is not sufficient to produce the preneoplastic phenotype of human breast cell line MCF10AT.

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Article

Activated c-Ha-ras is not sufficient to produce the preneoplastic phenotype of human breast cell line MCF10AT.

Anticancer research - 1 Jan 2000

Miller F R, Pauley R J, Wang B

Abstract excerpt

MCF10AT cells are human breast epithelial cells which are able to establish preneoplastic lesions in immune deficient mice. Although, the preneoplastic phenotype was observed following transfection with a mutated c-Ha-ras (codon 12 valine), clones of MCF10AT are unable to form lesions in vivo. Re...

Topics

Animals
Blotting, Western
Breast
Cell Line
Codon
Female
Genes, ras
Humans
Mice
Mice, Nude
Phenotype
Point Mutation
Precancerous Conditions
Proto-Oncogene Proteins p21(ras)
Stem Cells
Transfection
Transplantation, Heterologous
Valine

Source

Open in PubMed

Identifiers

PMID: 8712698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8712698-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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