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Article

Transformation of Human Breast Epithelial Cells by c‐Ha‐<i>ras</i> Oncogene

1 Jan 1991

Abstract excerpt

To determine whether the c-Ha-ras oncogene plays a role in the initiation of mammary carcinogenesis, an immortalized human breast epithelial cell line, MCF-10A, was transfected with the plasmid vector pHo6T1 containing the T24 Ha-ras oncogene and the aminoglycoside phosphotransferase gene, which confers resistance to geneticin. Transfected cells exhibited an altered pattern of growth and tridimensional morphology...

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PMID: 2009132
DOI: 10.1002/mc.2940040106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Transformation of Human Breast Epithelial Cells by c‐Ha‐<i>ras</i> OncogenePMID 2009132Read ↗

Morphological expression of cell transformation induced by c-Ha-ras oncogene in human breast epithelial cells.Semantic proximity Read ↗

Mutated c-Ha-ras oncogene alters cytokeratin expression in the human breast epithelial cell line MCF-10A.Semantic proximity Read ↗

Transforming growth factor (TGF)-β in conjunction with H-ras activation promotes malignant progression of MCF10A breast epithelial cellsSemantic proximity Read ↗

Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane cultureSemantic proximity Read ↗

Oncoprotein expression and morphological phenotypes of human breast epithelial cells transformed by the c-Ha-ras oncogene.Semantic proximity Read ↗

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