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Article

Protective mechanisms of p53-p21-pRb proteins against DNA damage-induced cell death

1 Feb 2008

Abstract excerpt

There have been innumerate demonstrations of p53's activity as a tumour suppressor protein with the ability to stimulate cell signalling that can lead to cell cycle arrest and cell death in the event of DNA damage. Despite the solid body of evidence to support these properties of p53, reports have emerged that suggest a role for p53 in protecting cells from cell death. Our recent report highlighted a mechanism by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 18235223
DOI: 10.4161/cc.7.3.5328

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