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Article

Impaired immune responses and altered peptide repertoire in tapasin-deficient mice.

Nature immunology - 1 Sept 2000

Garbi N, Tan P, Diehl A D, Chambers B J, Ljunggren H G, Momburg F, Hämmerling G J

Abstract excerpt

Tapasin is a component of the major histocompatibility complex (MHC) class I antigen-loading complex. Here we show that mice with a disrupted tapasin gene display reduced MHC class I expression. Cytotoxic T cell (CTL) responses to viruses are impaired, and dendritic cells of tapasin-deficient mice do not cross-present protein antigen via the MHC class I pathway, indicating a defect in antigen processing. Natural...

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Identifiers

PMID: 10973281
DOI: 10.1038/79775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Impaired immune responses and altered peptide repertoire in tapasin-deficient mice.PMID 10973281Read ↗

Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice.Semantic proximity Read ↗

HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading.Semantic proximity Read ↗

Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220.Semantic proximity Read ↗

Quantitative and Qualitative Influences of Tapasin on the Class I Peptide RepertoireSemantic proximity Read ↗

Phenotypic and pathomechanistic overlap between tapasin and TAP deficiencies.Semantic proximity Read ↗

A mechanistic basis for the co-evolution of chicken tapasin and major histocompatibility complex class I (MHC I) proteins.Semantic proximity Read ↗

Distinct functions of tapasin revealed by polymorphism in MHC class I peptide loading.Semantic proximity Read ↗

Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.Semantic proximity Read ↗

Critical role for the tapasin-docking site of TAP2 in the functional integrity of the MHC class I-peptide-loading complex.Semantic proximity Read ↗

The cell biology of major histocompatibility complex class I assembly: towards a molecular understandingSemantic proximity Read ↗

The role of tapasin in MHC class 1 antigen presentationSemantic proximity Read ↗

Asymptomatic deficiency in the peptide transporter associated to antigen processing (TAP).Semantic proximity Read ↗

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