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Article

Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated states.

The Journal of physiology - 15 Jan 1998

Jäger H, Rauer H, Nguyen A N, Aiyar J, Chandy K G, Grissmer S

Abstract excerpt

1. Using the whole-cell recording mode we have characterized two non-conducting states in mammalian Shaker-related voltage-gated K+ channels induced by the removal of extracellular potassium, K+o. 2. In the absence of K+o, current through Kv1.4 was almost completely abolished due to the presence of a charged lysine residue at position 533 at the entrance to the pore. Removal of K+o had a similar effect on current...

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Identifiers

PMID: 9490854
DOI: 10.1111/j.1469-7793.1998.291bw.x
PMCID: PMC2230732

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Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated states.PMID 9490854Read ↗

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