Article
Identification of Legionella pneumophila mutants that have aberrant intracellular fates.
Infection and immunity - 1 Jul 1996
Swanson M S, Isberg R R
Abstract excerpt
After uptake by macrophages, Legionella pneumiophila evades phagosome-lysosome fusion and replicates in a compartment associated with the endoplasmic reticulum. A collection of bacterial mutants defective for growth in macrophages were isolated, and the intracellular fate of each mutant strain was analyzed by fluorescence microscopy. To measure intracellular replication, bacteria inside macrophages were stained...
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