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Article

Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes.

Oncogene - 12 Feb 1998

Amundadottir L T, Leder P

Abstract excerpt

We have assessed five signal transduction pathways to determine the role each might play in the malignant transformation of mammary epithelium initiated by neu, heregulin/NDF, TGFalpha, v-Ha-ras and c-myc in transgenic mice. The study involves a molecular and pharmacologic assessment of Erk/MAP kinase, Jnk/SAP kinase, PI 3-kinase, protein kinase C, and the Src-related kinases Lck and Fyn. Our results indicate...

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Identifiers

PMID: 9488037
DOI: 10.1038/sj.onc.1201829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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