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Article

Coupling of RAFTK/Pyk2 kinase with c-Abl and their role in the migration of breast cancer cells.

International journal of oncology - 1 Jan 2004

Zrihan-Licht Sheila, Avraham Shalom, Jiang Shuxian, Fu Yigong, Avraham Hava Karsenty

Abstract excerpt

Mitogen-induced changes in the actin cytoskeleton are accompanied by changes in the tyrosine phosphorylation of several proteins in focal adhesions. In this study, we have investigated the role of RAFTK (also termed Pyk2/CAK-beta), a cytoplasmic tyrosine kinase related to focal adhesion kinase (FAK), in heregulin-mediated signal transduction in breast cancer cells. Stimulation of T47D cells with heregulin (HRG)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14654952

Genes

HRG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Coupling of RAFTK/Pyk2 kinase with c-Abl and their role in the migration of breast cancer cells.PMID 14654952Read ↗

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Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.Semantic proximity Read ↗

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