Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vivo function of mutated spliced leader RNAs in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 1998

Xie H, Hirsh D

Abstract excerpt

The role of spliced leader RNA (SL RNA) in trans-splicing in Caenorhabditis elegans has been studied through a combination of in vitro mutagenesis and in vivo complementation of rrs-1 mutant nematodes, which lack endogenous SL1 RNA. Three classes of mutant SL1 RNAs have been found-those that rescue the lethal phenotype at low concentration of transforming DNA, those that rescue at high but not low concentration,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA Primers
Share to Genetic Complementation Test

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutagenesis

Share to Phenotype

Share to Polymerase Chain Reaction

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 9539720
DOI: 10.1073/pnas.95.8.4235
PMCID: PMC22472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo function of mutated spliced leader RNAs in Caenorhabditis elegans.PMID 9539720Read ↗

The SL1 trans-spliced leader RNA performs an essential embryonic function in Caenorhabditis elegans that can also be supplied by SL2 RNA.Semantic proximity Read ↗

Splicing removes the Caenorhabditis elegans transposon Tc1 from most mutant pre-mRNAs.Semantic proximity Read ↗

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.Semantic proximity Read ↗

Functional analysis of an intron 3' splice site in Caenorhabditis elegans.Semantic proximity Read ↗

Multiple requirements for nematode spliced leader RNP function in trans-splicing.Semantic proximity Read ↗

Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.Semantic proximity Read ↗

Imprecise excision of the Caenorhabditis elegans transposon Tc1 creates functional 5' splice sites.Semantic proximity Read ↗

A forward genetic screen in C. elegans identifies conserved residues of spliceosomal proteins PRP8 and SNRNP200/BRR2 with a role in maintaining 5' splice site identity.Semantic proximity Read ↗

High-throughput reverse genetics: RNAi screens in Caenorhabditis elegans.Semantic proximity Read ↗

Intramolecular base pairing between the nematode spliced leader and its 5' splice site is not essential for trans-splicing in vitro.Semantic proximity Read ↗

RNAi mechanisms in Caenorhabditis elegans.Semantic proximity Read ↗

C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.