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Article

Genetic disruption of atrial natriuretic peptide receptor-A alters renin and angiotensin II levels.

American journal of physiology. Renal physiology - 1 Oct 2001

Shi S J, Nguyen H T, Sharma G D, Navar L G, Pandey K N

Abstract excerpt

We have studied cardiovascular and renal phenotypes in Npr1 (genetic determinant of natriuretic peptide receptor-A; NPRA) gene-disrupted mutant mouse model. The baseline systolic arterial pressure (SAP) in 0-copy mutant (-/-) mice (143 +/- 2 mmHg) was significantly higher than in 2-copy wild-type (+/+) animals (104 +/- 2 mmHg); however, the SAP in 1-copy heterozygotes (+/-) was at an intermediate value (120 +/- 4...

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Source

Identifiers

PMID: 11553513
DOI: 10.1152/ajprenal.2001.281.4.F665

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ANG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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