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Article

Association between homeobox-containing gene MSX1 and the occurrence of limb deficiency.

American journal of medical genetics - 3 Feb 1998

Hwang S J, Beaty T H, McIntosh I, Hefferon T, Panny S R

Abstract excerpt

Animal studies have suggested an important role for the homeobox-containing gene MSX1 in limb, oralfacial, and cardiac malformations. In this study of 516 Caucasians with isolated birth defects registered in the Maryland Birth Defects Reporting and Information System (BDRIS), we report an association between a dinucleotide repeat polymorphism in MSX1 and isolated limb deficiency. Frequencies of rare alleles at...

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Source

Identifiers

PMID: 9482651

Genes

MSX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The MSX1 allele 4 homozygous child exposed to smoking at periconception is most sensitive in developing nonsyndromic orofacial clefts.Semantic proximity Read ↗

Family-based analysis of MSX1 haplotypes for association with oral clefts.Semantic proximity Read ↗

Absence of mutations in the homeodomain of theMSX1 gene in patients with hypodontiaSemantic proximity Read ↗

[Genetic variation of MSX1 has a sexual dimorphism in non syndromic cleft palate in the Chilean population].Semantic proximity Read ↗

Smoking, the xenobiotic pathway, and clubfoot.Semantic proximity Read ↗

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