Article
A human MSX1 homeodomain missense mutation causes selective tooth agenesis.
Nature genetics - 1 Aug 1996
Vastardis H, Karimbux N, Guthua S W, Seidman J G, Seidman C E
Abstract excerpt
We demonstrate that a mutation in the homeobox gene, MSX1, causes a common developmental anomaly, familial tooth agenesis. Genetic linkage analyses in a family with autosomal dominant agenesis of second premolars and third molars identified a locus on chromosome 4p, where the MSX1 gene resides. S...
Topics
- Alleles
- Amino Acid Sequence
- Anodontia
- Base Sequence
- Chromosomes, Human, Pair 4
- DNA Primers
- Female
- Genes, Dominant
- Genes, Homeobox
- Genetic Linkage
- Homeodomain Proteins
- Humans
- MSX1 Transcription Factor
- Male
- Molecular Sequence Data
- Pedigree
- Point Mutation
- Sequence Alignment