Article
The MSX1 allele 4 homozygous child exposed to smoking at periconception is most sensitive in developing nonsyndromic orofacial clefts.
Human genetics - 1 Dec 2008
van den Boogaard Marie-José H, de Costa Dominique, Krapels Ingrid P C, Liu Fan, van Duijn Cock, Sinke Richard J, Lindhout Dick, Steegers-Theunissen Régine P M
Abstract excerpt
Nonsyndromic orofacial clefts (OFC) are common birth defects caused by certain genes interacting with environmental factors. Mutations and association studies indicate that the homeobox gene MSX1 plays a role in human clefting. In a Dutch case-control triad study (mother, father, and child), we investigated interactions between MSX1 and the parents' periconceptional lifestyle in relation to the risk of OFC in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.