Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells.

The Journal of biological chemistry - 27 Feb 1998

Xing S, Furminger T L, Tong Q, Jhiang S M

Abstract excerpt

Gene alterations in the ret proto-oncogene, which encodes a receptor tyrosine kinase, have been found to associate with several human diseases. In this study, we showed that induction of the vgf promoter activity is a good molecular indicator for RET activation in PC12 cells, a rat pheochromocytoma cell line. We demonstrated that all forms of RET oncoprotein, including RET chimeric oncoproteins found in human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Drosophila Proteins
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Phosphorylation

Share to Promoter Regions, Genetic

Share to Protein Biosynthesis

Share to Proteins

Source

Identifiers

PMID: 9478934
DOI: 10.1074/jbc.273.9.4909

Genes

RET
JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells.PMID 9478934Read ↗

RET and neuroendocrine tumors.Semantic proximity Read ↗

Different mutations of the RET gene cause different human tumoral diseases.Semantic proximity Read ↗

Expression of the RET oncogene induces differentiation of SK-N-BE neuroblastoma cells.Semantic proximity Read ↗

Glial cell line-derived neurotrophic factor differentially stimulates ret mutants associated with the multiple endocrine neoplasia type 2 syndromes and Hirschsprung's disease.Semantic proximity Read ↗

The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes.Semantic proximity Read ↗

Expression of the RET proto-oncogene in normal human tissues, pheochromocytomas, and other tumors of neural crest originSemantic proximity Read ↗

Characterization of Ret-Shc-Grb2 complex induced by GDNF, MEN 2A, and MEN 2B mutations.Semantic proximity Read ↗

Ret oncogene signal transduction via a IRS-2/PI 3-kinase/PKB and a SHC/Grb-2 dependent pathway: possible implication for transforming activity in NIH3T3 cells.Semantic proximity Read ↗

Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cells.Semantic proximity Read ↗

Molecular mechanism of activation and superactivation of Ret tyrosine kinases by ultraviolet light irradiation.Semantic proximity Read ↗

The tyrosine phosphatase Shp-2 mediates intracellular signaling initiated by Ret mutants.Semantic proximity Read ↗

Ligand stimulation of a Ret chimeric receptor carrying the activating mutation responsible for the multiple endocrine neoplasia type 2B.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.