Article
Molecular mechanism of activation and superactivation of Ret tyrosine kinases by ultraviolet light irradiation.
Antioxidants & redox signaling - 1 Jan 2000
Kato M, Iwashita T, Akhand A A, Liu W, Takeda K, Takeuchi K, Yoshihara M, Hossain K, Wu J, Du J, Oh C, Kawamoto Y, Suzuki H, Takahashi M, Nakashima I
Abstract excerpt
The catalytic activities of Ret tyrosine kinases as the products of oncogene RET with multiple endocrine neoplasia type 2A (Ret-MEN2A) or 2B (Ret-MEN2B) mutations and the hybrid gene from c-RET and RFP (Rfp-Ret) were higher than those of c-Ret. We demonstrated that ultraviolet light (UV) irradiation induced activation of c-Ret and superactivation of genetically mutated, and thereby constitutively activated,...
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