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Article

The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes.

Cellular signalling - 1 Jul 2004

Incoronato Mariarosaria, D'Alessio Amelia, Paladino Simona, Zurzolo Chiara, Carlomagno Maria Stella, Cerchia Laura, de Franciscis Vittorio

Abstract excerpt

The Shp-2 and Shp-1 non-transmembrane tyrosine phosphatases display different and even opposing effects on downstream signaling events initiated by Ret activation. By using rat pheochromocytoma-derived PC12 cells, here we studied the interactions of Shp-2 and Shp-1 with two activated mutants of Ret receptor, Ret(C634Y) and Ret(M918T). Each of these mutated receptors causes inheritance of distinct cancer...

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Identifiers

PMID: 15115663
DOI: 10.1016/j.cellsig.2004.01.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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