Article
Ligand stimulation of a Ret chimeric receptor carrying the activating mutation responsible for the multiple endocrine neoplasia type 2B.
The Journal of biological chemistry - 15 Nov 1996
Rizzo C, Califano D, Colucci-D'Amato G L, De Vita G, D'Alessio A, Dathan N A, Fusco A, Monaco C, Santelli G, Vecchio G, Santoro M, de Franciscis V
Abstract excerpt
Inherited activating mutations of Ret, a receptor tyrosine kinase, predispose to multiple endocrine neoplasia (MEN) types 2A and 2B and familial medullary thyroid carcinoma. To investigate the effects induced by acute stimulation of Ret, we transfected both PC12 and NIH 3T3 cells with a molecular construct in which the ligand-binding domain of the epidermal growth factor receptor was fused to the catalytic domain...
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