Article
Genetic screens for enhancers of brahma reveal functional interactions between the BRM chromatin-remodeling complex and the delta-notch signal transduction pathway in Drosophila.
Genetics - 1 Aug 2005
Armstrong Jennifer A, Sperling Adam S, Deuring Renate, Manning Laurina, Moseley Sarah L, Papoulas Ophelia, Piatek Caroline I, Doe Chris Q, Tamkun John W
Abstract excerpt
The Drosophila trithorax group gene brahma (brm) encodes the ATPase subunit of a 2-MDa chromatin-remodeling complex. brm was identified in a screen for transcriptional activators of homeotic genes and subsequently shown to play a global role in transcription by RNA polymerase II. To gain insight into the targeting, function, and regulation of the BRM complex, we screened for mutations that genetically interact...
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