Article
Native tertiary structure in an A-state.
Journal of molecular biology - 16 Jan 1998
Marmorino J L, Lehti M, Pielak G J
Abstract excerpt
The A-state is an equilibrium species that is thought to represent the molten globule, an on-pathway protein folding intermediate with native secondary structure and non-native, fluctuating tertiary structure. We used yeast iso-1-ferricytochrome c to test for an evolutionary-invariant tertiary interaction in its A-state. Thermal denaturation monitored by circular dichroism (CD)spectropolarimetry was used to...
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