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Article

Native hydrogen bonds in a molten globule: the apoflavodoxin thermal intermediate.

Journal of molecular biology - 2 Mar 2001

Irún M P, Garcia-Mira M M, Sanchez-Ruiz J M, Sancho J

Abstract excerpt

The structure and energetics of protein-folding intermediates are poorly understood. We have identified, in the thermal unfolding of the apoflavodoxin from Anabaena PCC 7119, an equilibrium intermediate with spectroscopic properties of a molten globule and substantial enthalpy and heat capacity of unfolding. The structure of the intermediate is probed by mutagenesis (and phi analysis) of polar residues involved...

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PMID: 11243795
DOI: 10.1006/jmbi.2001.4436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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