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Article

Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B.

Biochemical and biophysical research communications - 26 Jan 1998

Jang I K, Lee Z H, Kim Y J, Kim S H, Kwon B S

Abstract excerpt

Human 4-1BB (CD137), a member of the tumor necrosis factor receptor (TNFR) superfamily, costimulates T cell activation. No apparent intrinsic kinase activity is seen with 4-1BB, which suggests that 4-1BB-associated molecules may be involved in 4-1BB-mediated signal transduction. We found that tum...

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Source

Identifiers

PMID: 9464265
DOI: 10.1006/bbrc.1997.8016

Genes

TRAF2
TRAF3
TRAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9464265-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B.PMID 9464265Read ↗

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