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The relevance of soluble CD137 in the regulation of immune responses and for immunotherapeutic intervention

13 Feb 2020

Abstract excerpt

CD137 is a potent costimulatory receptor. Several agonistic anti-CD137 antibodies are currently in clinical trials for tumor immunotherapy. Soluble forms of CD137 (sCD137) are generated by differential splicing and antagonize the activities of membrane-bound CD137 (mCD137) and of therapeutic CD137 agonists. sCD137 is found in sera of patients suffering from autoimmune diseases where it is a natural regulator of...

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PMID: 32052477
DOI: 10.1002/jlb.2mr1119-224r

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