Article
Mining the National Cancer Institute Anticancer Drug Discovery Database: cluster analysis of ellipticine analogs with p53-inverse and central nervous system-selective patterns of activity.
Molecular pharmacology - 1 Feb 1998
Shi L M, Myers T G, Fan Y, O'Connor P M, Paull K D, Friend S H, Weinstein J N
Abstract excerpt
The United States National Cancer Institute conducts an anticancer drug discovery program in which approximately 10,000 compounds are screened every year in vitro against a panel of 60 human cancer cell lines from different organs. To date, approximately 62,000 compounds have been tested in the program, and a large amount of information on their activity patterns has been accumulated. For the current study,...
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