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Article

epsilon-COP is a structural component of coatomer that functions to stabilize alpha-COP.

The EMBO journal - 16 Feb 1998

Duden R, Kajikawa L, Wuestehube L, Schekman R

Abstract excerpt

We isolated a novel yeast alpha-COP mutant, ret1-3, in which alpha-COP is degraded after cells are shifted to a restrictive temperature. ret1-3 cells cease growth at 28 degrees C and accumulate the ER precursor of carboxypeptidase Y (p1 CPY). In a screen for high copy suppressors of these defects, we isolated the previously unidentified yeast epsilon-COP gene. epsilon-COP (Sec28p) overproduction suppresses the...

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Identifiers

PMID: 9463377
DOI: 10.1093/emboj/17.4.985
PMCID: PMC1170448

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