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Article

Non-clathrin-coat protein alpha is a conserved subunit of coatomer and in Saccharomyces cerevisiae is essential for growth.

Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 1995

Gerich B, Orci L, Tschochner H, Lottspeich F, Ravazzola M, Amherdt M, Wieland F, Harter C

Abstract excerpt

To complete the molecular characterization of coatomer, the preformed cytosolic complex that is involved in the formation of biosynthetic transport vesicles, we have cloned and characterized the gene for non-clathrin-coat protein alpha (alpha-COP) from Saccharomyces cerevisiae. The derived protein, molecular weight of 135,500, contains four WD-40 repeated motifs (Trp/Asp-containing motifs of approximately 40...

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Identifiers

PMID: 7724544
DOI: 10.1073/pnas.92.8.3229
PMCID: PMC42139

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non-clathrin-coat protein alpha is a conserved subunit of coatomer and in Saccharomyces cerevisiae is essential for growth.PMID 7724544Read ↗

Yeast beta- and beta'-coat proteins (COP). Two coatomer subunits essential for endoplasmic reticulum-to-Golgi protein traffic.Semantic proximity Read ↗

COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.Semantic proximity Read ↗

Assembly, organization, and function of the COPII coatSemantic proximity Read ↗

Identification and functional characterization of yeast zeta-COP.Semantic proximity Read ↗

Dsl1p, an essential component of the Golgi-endoplasmic reticulum retrieval system in yeast, uses the same sequence motif to interact with different subunits of the COPI vesicle coat.Semantic proximity Read ↗

Functional Validation of a COPA Mutation Broadens the Spectrum of COPA Syndrome.Semantic proximity Read ↗

Adaptor complex-independent clathrin function in yeast.Semantic proximity Read ↗

Coatopathies: Genetic Disorders of Protein CoatsSemantic proximity Read ↗

epsilon-COP is a structural component of coatomer that functions to stabilize alpha-COP.Semantic proximity Read ↗

Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval.Semantic proximity Read ↗

Suppression of coatomer mutants by a new protein family with COPI and COPII binding motifs in Saccharomyces cerevisiae.Semantic proximity Read ↗

Inherited hematological disorders due to defects in coat protein (COP)II complex.Semantic proximity Read ↗

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