Alpha-COP can discriminate between distinct, functional di-lysine signals in vitro and regulates access into retrograde transport.

doi:10.1242/jcs.111.23.3459

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Article

Alpha-COP can discriminate between distinct, functional di-lysine signals in vitro and regulates access into retrograde transport.

Journal of cell science - 1 Dec 1998

Schröder-Köhne S, Letourneur F, Riezman H

Abstract excerpt

Emp47p is a yeast Golgi transmembrane protein with a retrograde, Golgi to ER transport di-lysine signal in its cytoplasmic tail. Emp47p has previously been shown to recycle between the Golgi complex and the ER and to require its di-lysine signal for Golgi localization. In contrast to other protei...

Topics

Alleles
Amino Acid Sequence
Biological Transport, Active
Coatomer Protein
Cytosol
Dipeptides
Endoplasmic Reticulum
Fungal Proteins
Genes, Fungal
Golgi Apparatus
Hexosyltransferases
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Protein Binding

Protein Conformation

Recombinant Fusion Proteins

Saccharomyces cerevisiae

Source

Open in PubMed

Identifiers

PMID: 9811561
DOI: 10.1242/jcs.111.23.3459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9811561-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Alpha-COP can discriminate between distinct, functional di-lysine signals in vitro and regulates access into retrograde transport.PMID 9811561Read ↗

The alpha- and beta'-COP WD40 domains mediate cargo-selective interactions with distinct di-lysine motifs.Semantic proximity Read ↗

The Golgi-localization of yeast Emp47p depends on its di-lysine motif but is not affected by the ret1-1 mutation in alpha-COP.Semantic proximity Read ↗

Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval.Semantic proximity Read ↗

Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum.Semantic proximity Read ↗

Sec12p requires Rer1p for sorting to coatomer (COPI)-coated vesicles and retrieval to the ER.Semantic proximity Read ↗

epsilon-COP is a structural component of coatomer that functions to stabilize alpha-COP.Semantic proximity Read ↗

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Suppression of coatomer mutants by a new protein family with COPI and COPII binding motifs in Saccharomyces cerevisiae.Semantic proximity Read ↗

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