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Article

Suppression of coatomer mutants by a new protein family with COPI and COPII binding motifs in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Aug 2003

Sandmann Thomas, Herrmann Johannes M, Dengjel Jörn, Schwarz Heinz, Spang Anne

Abstract excerpt

Protein trafficking is achieved by a bidirectional vesicle flow between the various compartments of the eukaryotic cell. COPII coated vesicles mediate anterograde protein transport from the endoplasmic reticulum to the Golgi apparatus, whereas retrograde Golgi-to-endoplasmic reticulum vesicles use the COPI coat. Inactivation of COPI vesicle formation in conditional sec21 (gamma-COP) mutants rapidly blocks...

Topics

Amino Acid Motifs
Amino Acid Sequence
COP-Coated Vesicles
Cloning, Molecular
Endoplasmic Reticulum
Genotype
Golgi Apparatus
Membrane Proteins
Molecular Sequence Data
Mutation
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Transport

Saccharomyces cerevisiae

Vacuoles

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Identifiers

PMID: 12925749
DOI: 10.1091/mbc.e02-11-0736
PMCID: PMC181553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12925749-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Suppression of coatomer mutants by a new protein family with COPI and COPII binding motifs in Saccharomyces cerevisiae.PMID 12925749Read ↗

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The alpha- and beta'-COP WD40 domains mediate cargo-selective interactions with distinct di-lysine motifs.Semantic proximity Read ↗

Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum.Semantic proximity Read ↗

Multicopy suppressor analysis of thermosensitive YIP1 alleles implicates GOT1 in transport from the ER.Semantic proximity Read ↗

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Alpha-COP can discriminate between distinct, functional di-lysine signals in vitro and regulates access into retrograde transport.Semantic proximity Read ↗

Dsl1p, an essential component of the Golgi-endoplasmic reticulum retrieval system in yeast, uses the same sequence motif to interact with different subunits of the COPI vesicle coat.Semantic proximity Read ↗

Genes that control the fidelity of endoplasmic reticulum to Golgi transport identified as suppressors of vesicle budding mutations.Semantic proximity Read ↗

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