Article
Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study.
The Journal of antimicrobial chemotherapy - 1 Aug 2011
Prosperi Mattia C F, Mackie Nicola, Di Giambenedetto Simona, Zazzi Maurizio, Camacho Ricardo, Fanti Iuri, Torti Carlo, Sönnerborg Anders, Kaiser Rolf, Codoñer Francisco M, Van Laethem Kristel, Bansi Loveleen, van de Vijver David A M C, Geretti Anna Maria, De Luca Andrea
Abstract excerpt
BACKGROUND AND OBJECTIVES: Guidelines indicate a plasma HIV-1 RNA load of 500-1000 copies/mL as the minimal threshold for antiretroviral drug resistance testing. Resistance testing at lower viral load levels may be useful to guide timely treatment switches, although data on the clinical utility of this remain limited. We report here the influence of viral load levels on the probability of detecting drug...
Topics
- Adult
- Anti-HIV Agents
- CD4 Lymphocyte Count
- Cohort Studies
- Drug Resistance, Viral
- Europe
- Female
- Genotype
- HIV Infections
- HIV-1
- Humans
- Male
- Mutation, Missense