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Article

HIV-1 antiretroviral resistance: scientific principles and clinical applications.

Drugs - 18 Jun 2012

Tang Michele W, Shafer Robert W

Abstract excerpt

The efficacy of an antiretroviral (ARV) treatment regimen depends on the activity of the regimen's individual ARV drugs and the number of HIV-1 mutations required for the development of resistance to each ARV - the genetic barrier to resistance. ARV resistance impairs the response to therapy in patients with transmitted resistance, unsuccessful initial ARV therapy and multiple virological failures. Genotypic...

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Identifiers

PMID: 22686620
DOI: 10.2165/11633630-000000000-00000
PMCID: PMC3689909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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