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Article

ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase.

EMBO reports - 1 Apr 2007

Lee Sung Bae, Kim Sunhong, Lee Jiwoon, Park Jeehye, Lee Gina, Kim Yongsung, Kim Jin-Man, Chung Jongkyeong

Abstract excerpt

It has been proposed that cell growth and autophagy are coordinated in response to cellular nutrient status, but the relationship between them is not fully understood. Here, we have characterized the fly mutants of Autophagy-specific gene 1 (ATG1), an autophagy-regulating kinase, and found that ATG1 is a negative regulator of the target of rapamycin (TOR)/S6 kinase (S6K) pathway. Our Drosophila studies have shown...

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Identifiers

PMID: 17347671
DOI: 10.1038/sj.embor.7400917
PMCID: PMC1852764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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