Abnormalities in Alzheimer's disease fibroblasts bearing the APP670/671 mutation.

doi:10.1016/s0197-4580(97)00149-8

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Article

Abnormalities in Alzheimer's disease fibroblasts bearing the APP670/671 mutation.

Neurobiology of aging - 1 Jan 2000

Gibson G E, Vestling M, Zhang H, Szolosi S, Alkon D, Lannfelt L, Gandy S, Cowburn R F

Abstract excerpt

Abnormalities in cultured fibroblasts from familial Alzheimer's Disease (FAD) cases uniquely enable the determination of how gene defects alter cell biology in living tissue from affected individuals. The current study focused on measures of calcium regulation and oxidative metabolism in fibrobla...

Topics

Alzheimer Disease
Amyloid beta-Protein Precursor
Bombesin
Bradykinin
Calcimycin
Calcium
Fibroblasts
Humans
Ionophores
Ketoglutarate Dehydrogenase Complex
Mitochondria
Mutation
Signal Transduction

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