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Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.

Cell calcium - 1 Jun 2006

Zatti Giancarlo, Burgo Andrea, Giacomello Marta, Barbiero Laura, Ghidoni Roberta, Sinigaglia Giulietta, Florean Cristina, Bagnoli Silvia, Binetti Giuliano, Sorbi Sandro, Pizzo Paola, Fasolato Cristina

Abstract excerpt

Presenilin-1 and -2 (PS1 and PS2) mutations, the major cause of familial Alzheimer's disease (FAD), have been causally implicated in the pathogenesis of neuronal cell death through a perturbation of cellular Ca(2+) homeostasis. We have recently shown that, at variance with previous suggestions obtained in cells expressing other FAD-linked PS mutations, PS2-M239I and PS2-T122R cause a reduction and not an increase...

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PMID: 16620965
DOI: 10.1016/j.ceca.2006.03.002

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