Article
Highly polymorphic promoter regions of HLA DQA1 and DQB1 genes do not help to further define disease susceptibility in insulin-dependent diabetes mellitus.
Tissue antigens - 1 Dec 1997
Donner H, Rau H, Braun J, Herwig J, Usadel K H, Badenhoop K
Abstract excerpt
HLA DQA1, HLA DQB1 genes confer susceptibility to insulin-dependent (type 1) diabetes mellitus (IDDM). Since variants of their upstream regulatory regions are linked to the exons, we investigated their promoter polymorphisms (QAP and QBP) by a combination of PCR-based typing protocols in 136 IDDM...
Topics
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- Humans
- Polymorphism, Genetic
- Promoter Regions, Genetic