Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cumulus cells are required for the increased apoptotic potential in oocytes of aged mice

1 Dec 1997

Abstract excerpt

Recent studies with female ICR mice have suggested that oocyte DNA fragmentation is one reason for poor oocyte quality and lower fertility associated with ageing. Since it was not determined if this increased 'apoptotic' potential in aged oocytes is due to changes within the oocyte itself or within the microenvironment of cumulus cells (CC) surrounding the germ cell, we sought to clarify if CC were required to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lipid metabolism and biosynthesis
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9455852
DOI: 10.1093/humrep/12.12.2781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cumulus cells are required for the increased apoptotic potential in oocytes of aged micePMID 9455852Read ↗

Ovary and ovulation: DNA fragmentation of oocytes in aged miceSemantic proximity Read ↗

Low estrogen level in aged mice leads to abnormal oogenesis affecting the quality of surrounded nucleolus-type immature oocytesSemantic proximity Read ↗

Reduced developmental competence of immature, in-vitro matured and postovulatory aged mouse oocytes following IVF and ICSISemantic proximity Read ↗

Poor Embryo Development in Mouse Oocytes Aged In Vitro Is Associated with Impaired Calcium Homeostasis1Semantic proximity Read ↗

A central role for ceramide in the age‐related acceleration of apoptosis in the female germlineSemantic proximity Read ↗

Poor embryo development in post-ovulatory <i>in vivo</i> -aged mouse oocytes is associated with mitochondrial dysfunction, but mitochondrial transfer from somatic cells is not sufficient for rejuvenationSemantic proximity Read ↗

Oocyte senescence: A firm link to age-related female subfertilitySemantic proximity Read ↗

Dithiothreitol prevents age-associated decrease in oocyte/conceptus viability in vitroSemantic proximity Read ↗

Effect of Female Age on Mouse Oocyte Developmental Competence Following Mitochondrial Injury1Semantic proximity Read ↗

Melatonin Prevents Postovulatory Oocyte Aging in the Mouse and Extends the Window for Optimal Fertilization In Vitro1Semantic proximity Read ↗

Alterations in oocyte mitochondrial number and function are related to spindle defects and occur with maternal aging in mice and humans†Semantic proximity Read ↗

SCM-198 ameliorates the quality of postovulatory and maternally aged oocytes by reducing oxidative stressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.