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Article

Effect of Female Age on Mouse Oocyte Developmental Competence Following Mitochondrial Injury1

21 Apr 2005

Abstract excerpt

Oocytes from aging ovaries contain mitochondria with morphological and genetic flaws. How these flaws relate to phenotypes of oocyte developmental compromise associated with clinical infertility is not well understood. This study was conducted to investigate the role of mitochondria in the developmental compromises observed with female aging using a mouse model of mitochondrial dysfunction. Oocytes obtained from...

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Identifiers

PMID: 15843494
DOI: 10.1095/biolreprod.105.040956

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