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Article

Dithiothreitol prevents age-associated decrease in oocyte/conceptus viability in vitro

1 Feb 1998

Abstract excerpt

The present study was designed to ascertain whether the negative effects on reproductive potential of post-ovulatory ageing in vitro of oocytes can be prevented by antioxidant therapy. Mouse metaphase II (MII) oocytes were aged in vitro for 12 h prior to insemination in the presence of varying concentrations of L-ascorbic acid, 6-methoxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox), L-cystine...

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PMID: 9557843
DOI: 10.1093/humrep/13.2.381

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