Article
Oocyte senescence: A firm link to age-related female subfertility
1 Jan 2008
Abstract excerpt
In women optimal fertility is maintained until 30 years of age and then decreases sharply. Therefore, the trend to delay childbearing until the fourth decade of life has contributed highly to the decline in total fertility rate observed in Western countries in recent decades. Much evidence supports the idea that age-related subfertility is mostly related to oocyte senescence. Based on the finding that maternal...